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KMID : 0895820060160030001
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Journal of Oriental Rehabilitation Medicine
2006 Volume.16 No. 3 p.1 ~ p.16
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Inhibitory Effect of Kuseupbokhap-bang(Qushl fuhe-fang) on Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes
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Han Joo-Won
Song Young-Il
Yoon Il-Ji
Oh Min-Seok
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Abstract
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Objectives: This study was carried out to know the inhibitory effect of Kuseupbokhap-bang(Qush?fuhe-f?ng; KC) on rheumatoid arthritis in human fibroblast-like synoviocytes(hFLSs).
Methods: For this purpose, experiments were performed to measure the cytotoxicity against hFCs and the production of pro-inflammatory cytokines in hFLSs and the production of NO, ROS.
Results: KC had no cytotoxicity against hFCs and reduced the production of pro-inflammatory cytokines TNF-α, IL-6, IL-8, IL-1β in hFLSs, increased the production of TIMP-1. As well as KC reduced the production of MMP-3, NOS-II, ICAM-1, the production of Nitric oxide and ROS, and the proliferation of hFLSs in proportion to the concentration of KC significantly.
Conclusions: Comparison of the results for this study showed that KC had immunomodulatory effects of suppressing or enhancing.
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KEYWORD
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Kuseupbokhap-bang(Qush?fuhe-f?ng), Rheumatoid arthritis, Immunomodulatory, Immunity, Collagen-induced arthritis(CIA) mice
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